The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies
Abstract WHO-defined SARS-CoV-2 variants of concern (VOC) drive therapeutics and
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …
[HTML][HTML] An overview on the treatments and prevention against COVID-19
Y Panahi, AM Gorabi, S Talaei, F Beiraghdar… - Virology Journal, 2023 - Springer
Background The coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …
[HTML][HTML] Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution
Continuous evolution of Omicron has led to a rapid and simultaneous emergence of
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …
numerous variants that display growth advantages over BA. 5 (ref.). Despite their divergent …
[HTML][HTML] Emergence of SARS-CoV-2 omicron lineages BA. 4 and BA. 5 in South Africa
Abstract Three lineages (BA. 1, BA. 2 and BA. 3) of the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) Omicron variant of concern predominantly drove South Africa's …
coronavirus 2 (SARS-CoV-2) Omicron variant of concern predominantly drove South Africa's …
Antigenicity and infectivity characterisation of SARS-CoV-2 BA. 2.86
S Yang, Y Yu, F Jian, W Song, A Yisimayi… - The Lancet Infectious …, 2023 - thelancet.com
The newly emerged SARS-CoV-2 saltation variant, BA. 2.86, has raised global concern
(appendix 1 p 7). By Sept 8, 2023, 95 sequences were detected, of which their early …
(appendix 1 p 7). By Sept 8, 2023, 95 sequences were detected, of which their early …
Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness
Repeated emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased fitness underscores the value of rapid detection and characterization …
variants with increased fitness underscores the value of rapid detection and characterization …
[HTML][HTML] Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA. 1 and BA. 2 receptor-binding domains
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD)
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …
[HTML][HTML] A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike
B Dadonaite, KHD Crawford, CE Radford, AG Farrell… - Cell, 2023 - cell.com
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
functional effects of emerging mutations in the viral spike protein. Here, we describe a deep …
Continued emergence and evolution of Omicron in South Africa: New BA. 4 and BA. 5 lineages
South Africa's fourth COVID-19 wave was driven predominantly by three lineages (BA. 1, BA.
2 and BA. 3) of the SARS-CoV-2 Omicron variant of concern. We have now identified two …
2 and BA. 3) of the SARS-CoV-2 Omicron variant of concern. We have now identified two …
[HTML][HTML] Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages have
escaped most receptor-binding domain (RBD)-targeting therapeutic neutralizing antibodies …
escaped most receptor-binding domain (RBD)-targeting therapeutic neutralizing antibodies …