Cancer genomics research aims to advance personalized oncology by finding and targeting
specific genetic alterations associated with cancers. In genome-driven oncology, treatments …

Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful technology used to investigate the spatial distributions of thousands of molecules …

Diffuse intrinsic pontine glioma (DIPG) remains a fatal brainstem tumor demanding
innovative therapies. As B7-H3 (CD276) is expressed on central nervous system (CNS) …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Among the pleotropic roles of transforming growth factor–β (TGFβ) signaling in cancer, its
impact on genomic stability is least understood. Inhibition of TGFβ signaling increases use of …

Introduction Many pathologies, including cancer, have been associated with aberrant
phosphorylation-mediated signaling networks that drive altered cell proliferation, migration …

Oral squamous cell carcinoma (OSCC) has become a global health problem due to its
increasing incidence and high mortality rate. Early intervention through monitoring of the …

Immunotherapies are revolutionizing cancer care, producing durable responses and
potentially cures in a subset of patients. However, response rates are low for most tumors …

Background AZD0156 and AZD6738 are potent and selective inhibitors of ataxia-
telangiectasia-kinase (ATM) and ataxia-telangiectasia-mutated and Rad3-related (ATR) …

A primary goal of the US National Cancer Institute's Ras initiative at the Frederick National
Laboratory for Cancer Research is to develop methods to quantify RAS signaling to facilitate …