Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …

Abstract Chagas disease and Human African Trypanosomiasis (HAT) are caused by
Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain …

A group of seventeen communicable and poverty-related diseases are considered
neglected by the World Health Organization due to the restricted development of diagnostic …

Several valuable biologically active molecules can be obtained through C–H activation
processes. However, the use of expensive and not readily accessible catalysts complicates …

Parasitic diseases are a neglected and serious problem, especially in underdeveloped
countries. Among the major parasitic diseases, Leishmaniasis figures as an urgent …

Organometallic moieties make excellent candidates for lead structures in drug design, due
to their bioactivity, redox chemistry and structural diversity. Despite this, only a limited …

Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant
human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease …

The development of safe and affordable antiparasitic agents effective against neglected
tropical diseases is a big challenge of the drug discovery. The drugs currently employed …