[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological Reviews, 2023 - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

[HTML][HTML] Sleep, circadian biology and skeletal muscle interactions: Implications for metabolic health

M Morrison, SL Halson, J Weakley, JA Hawley - Sleep medicine reviews, 2022 - Elsevier
There currently exists a modern epidemic of sleep loss, triggered by the changing demands
of our 21st century lifestyle that embrace 'round-the-clock'remote working hours, access to …

Circadian rhythm disruption in critically ill patients

M Felten, C Dame, G Lachmann, C Spies… - Acta …, 2023 - Wiley Online Library
Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …

Effect of circadian rhythm disturbance on the human musculoskeletal system and the importance of nutritional strategies

N Juliana, L Azmi, NM Effendy, NI Mohd Fahmi Teng… - Nutrients, 2023 - mdpi.com
The circadian system in the human body responds to daily environmental changes to
optimise behaviour according to the biological clock and also influences various …

Physical activity as a promising alternative for young people with juvenile idiopathic arthritis: Towards an evidence-based prescription

E Rochette, O Saidi, É Merlin, P Duché - Frontiers in Immunology, 2023 - frontiersin.org
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in young people.
Although biologics now enable most children and adolescents with JIA to enjoy clinical …

[HTML][HTML] Effects of morning vs. evening exercise on appetite, energy intake, performance and metabolism, in lean males and females

WJA Mode, T Slater, MG Pinkney, J Hough, RM James… - Appetite, 2023 - Elsevier
Exercise is an important component of a weight management strategy. However, little is
known about whether circadian variations in physiological and behavioural processes can …

[HTML][HTML] Multi-omic identification of key transcriptional regulatory programs during endurance exercise training

GR Smith, B Zhao, ME Lindholm, A Raja, M Viggars… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Transcription factors (TFs) play a key role in regulating gene expression and responses to
stimuli. We conducted an integrated analysis of chromatin accessibility, DNA methylation …

The role of circadian rhythm in osteoporosis; a review

Y Tian, J Ming - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Osteoporosis is characterized by a high incidence rate, with significant effects on people's
lives. The underlying mechanisms are complex, with no treatments for the condition. Recent …

Homo sapiens May Incorporate Daily Acute Cycles of “Conditioning–Deconditioning” to Maintain Musculoskeletal Integrity: Need to Integrate with Biological Clocks …

DA Hart, RF Zernicke, NG Shrive - International Journal of Molecular …, 2022 - mdpi.com
Human evolution required adaptation to the boundary conditions of Earth, including 1 g
gravity. The bipedal mobility of Homo sapiens in that gravitational field causes ground …

Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and …

W Dioh, V Narkar, A Singh, F Malik… - The Journals of …, 2023 - academic.oup.com
In recent years, several new classes of therapies have been investigated with their potential
for restoring or improving physical functioning in older adults. These have included Mas …