Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Preeclampsia: updates in pathogenesis, definitions, and guidelines

E Phipps, D Prasanna, W Brima… - Clinical Journal of the …, 2016 - journals.lww.com
Preeclampsia is becoming an increasingly common diagnosis in the developed world and
remains a high cause of maternal and fetal morbidity and mortality in the developing world …

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

Matrix metalloproteinases in normal pregnancy and preeclampsia

J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Pathogenesis of preeclampsia

M Sircar, R Thadhani… - Current opinion in …, 2015 - journals.lww.com
Pathogenesis of preeclampsia : Current Opinion in Nephrology and Hypertension Pathogenesis
of preeclampsia : Current Opinion in Nephrology and Hypertension Log in or Register …

Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia

JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

The role of aspirin, heparin, and other interventions in the prevention and treatment of fetal growth restriction

KM Groom, AL David - American journal of obstetrics and gynecology, 2018 - Elsevier
Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth,
and placental abruption are believed to arise in early pregnancy when inadequate …

Hydrogen sulfide: an emerging precision strategy for gas therapy

H Ding, J Chang, F He, S Gai… - Advanced Healthcare …, 2022 - Wiley Online Library
Advances in nanotechnology have enabled the rapid development of stimuli‐responsive
therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H2S) is a significant …