Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …

Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of
p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent …

Ki-67 serves as a prominent cancer marker. We describe how expression of the MKI67 gene
coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Most human cancers acquire mutations causing defects in the p53 signaling pathway. The
tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for …

Perfectly orchestrated periodic gene expression during cell cycle progression is essential for
maintaining genome integrity and ensuring that cell proliferation can be stopped by …

Bladder cancer is one of the most lethal cancers in the world. Despite the continuous
development of medical technologies and therapeutic strategies, the overall survival rate of …

High risk human papilloma viruses cause several types of cancer. The HPV oncoproteins E6
and E7 are essential for oncogenic cell transformation. E6 mediates the degradation of the …

Histone deacetylases (HDACs) play a crucial role in transcriptional regulation and are
implicated in various diseases, including cancer. They are involved in histone tail …

Cell cycle gene expression occurs in two waves. The G1/S genes encode factors required
for DNA synthesis and the G2/M genes contribute to mitosis. The Retinoblastoma protein …