The carbamate group is a key structural motif in many approved drugs and prodrugs. There
is an increasing use of carbamates in medicinal chemistry and many derivatives are …

Because of a preconceived notion that eliminating reactive metabolite (RM) formation with
new drug candidates could mitigate the risk of idiosyncratic drug toxicity, the potential for RM …

COVID-19 is announced as a global pandemic in 2020. Its mortality and morbidity rate are
rapidly increasing, with limited medications. The emergent outbreak of COVID-19 prompted …

South Africa has the largest occurrence of the human immune deficiency virus (HIV) in the
world but has also implemented the largest antiretroviral (ARV) treatment programme. It was …

Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

The sources, ecotoxicological impact, and potential remediation strategies of antiretroviral
drugs (ARVDs) as emerging contaminants in surface waters are reviewed based on recent …

Darunavir, an anti-HIV drug having poor solubility in aqueous and lipid medium, illustrates
degradation above its melting point, ie 74° C, thus, posing a challenge to dosage …

Background Cobicistat is an alternative pharmacoenhancer to ritonavir. In healthy
volunteers, darunavir exposure was comparable when darunavir 800 mg once daily was co …

Abstract The recent pandemic, Coronavirus Disease 2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has devastated humanity and is …

Maximal and durable viral load suppression is one of the most important goals of HIV
therapy and is directly related to adequate drug exposure. Protease inhibitors (PIs), an …