Nanomedicines in the management of Alzheimer's disease: current view and future prospects

H Chopra, S Bibi, I Singh, MA Kamal, F Islam… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a kind of dementia that creates serious challenges for sufferers'
memory, thinking, and behavior. It commonly targeting the aging population and decay the …

Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases

A Khalil, A Barras, R Boukherroub, CL Tseng… - Nanoscale …, 2024 - pubs.rsc.org
Paracellular permeability across epithelial and endothelial cells is, in large part, regulated
by apical intercellular junctions also referred to as tight junctions (TJs). These junctions …

Intranasal cerium oxide nanoparticles ameliorate cognitive function in rats with Alzheimer's via anti-oxidative pathway

SM Danish, A Gupta, UA Khan, N Hasan, FJ Ahmad… - Pharmaceutics, 2022 - mdpi.com
Cerium oxide nanoparticles (CNPs), owing to their antioxidant property, have recently
emerged as therapeutic candidate for Alzheimer's disease (AD). However, intravenous …

Understanding the phagocytosis of particles: the key for rational design of vaccines and therapeutics

S Moreno-Mendieta, D Guillén… - Pharmaceutical …, 2022 - Springer
A robust comprehension of phagocytosis is crucial for understanding its importance in innate
immunity. A detailed description of the molecular mechanisms that lead to the uptake and …

Sirolimus loaded chitosan functionalized PLGA nanoparticles protect against sodium iodate-induced retinal degeneration

R Suri, TC Nag, N Mehra, YR Neupane, S Shafi… - Journal of Drug Delivery …, 2023 - Elsevier
Age-related macular degeneration (AMD) is a major health concern in the ageing human
population. Though existing therapeutics have shown some efficacy, low retinal …

Engineering of structural and functional properties of nanotherapeutics and nanodiagnostics for intranasal brain targeting in Alzheimer's

NS Hinge, H Kathuria, MM Pandey - Applied Materials Today, 2022 - Elsevier
Alzheimer's disease (AD) is the fifth leading cause of death on the planet. It hallmarks the
presence of amyloid plaques and neurofibrillary tangles in geriatric patients. The condition …

Intranasal inorganic cerium oxide nanoparticles ameliorate oxidative stress induced motor manifestations in haloperidol-induced parkinsonism

Mohammad, UA Khan, Z Saifi, J Bora, MH Warsi… - …, 2023 - Springer
Cerium oxide nanoparticles (CONPs), owing to their radical scavenging property, have
recently emerged as a therapeutic candidate for oxidative stress-mediated neurological …

A New Perspective on the Treatment of Alzheimer's Disease and Sleep Deprivation‐Related Consequences: Can Curcumin Help?

E Küpeli Akkol, H Bardakcı, Ç Yücel… - Oxidative Medicine …, 2022 - Wiley Online Library
Sleep disturbances, as well as sleep‐wake rhythm disorders, are characteristic symptoms of
Alzheimer's disease (AD) that may head the other clinical signs of this neurodegenerative …

How nano-engineered delivery systems can help marketed and repurposed drugs in Alzheimer's disease treatment?

L Séguy, AC Groo, A Malzert-Freon - Drug Discovery Today, 2022 - Elsevier
Highlights•Alzheimer's disease (AD) is drastically lacking of curative treatment.•The interest
of nanocarriers for the approved drugs in AD treatment has been shown.•Drug repurposing …

[HTML][HTML] Curcumin/TGF-β1 siRNA loaded solid lipid nanoparticles alleviate cerebral injury after intracerebral hemorrhage by transnasal brain targeting

M Abudurexiti, J Xue, X Li, X Zhang, Y Qiu… - Colloids and Surfaces B …, 2024 - Elsevier
Intracerebral hemorrhage (ICH) is a prevalent cerebrovascular disorder. The inflammation
induced by cerebral hemorrhage plays a crucial role in the secondary injury of ICH and often …