Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

The completion of the Human Genome Project has provided a foundational blueprint for
understanding human life. Nonetheless, understanding the intricate mechanisms through …

Glioblastoma, the most aggressive primary brain cancer, has a dismal prognosis, yet
systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies …

While heterogeneity is a key feature of cancer, understanding metabolic heterogeneity at the
single-cell level remains a challenge. Here we present 13C-SpaceM, a method for spatial …

Resistance to genotoxic therapies and tumor recurrence are hallmarks of glioblastoma
(GBM), an aggressive brain tumor. In this study, we investigated functional drivers of post …

Human tumors are intricate ecosystems composed of diverse genetic clones and malignant
cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing …

Glioblastoma is the deadliest brain cancer, characterized by great cellular diversity and
unique histology. To understand the spatial organization of transcriptional cell states, we …

Tumor evolution is driven by genetic variation; however, it is the tumor microenvironment
(TME) that provides the selective pressure contributing to evolution in cancer. Despite high …

Glioblastoma (GBM) displays an infiltrative growth characteristic that recruits neighboring
normal cells to facilitate tumor growth, maintenance, and invasion into the brain. While the …

There is a renewed interest in neutrophil biology, largely instigated by their prominence in
cancer. From an immunologist's perspective, a conceptual breakthrough is the realization …