Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …

Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

Solid tumors have developed robust ferroptosis resistance. The mechanism underlying
ferroptosis resistance regulation in solid tumors, however, remains elusive. Here, we report …

The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in the cellular response to hypoxia
by regulating the expression of many genes involved in adaptive processes that allow cell …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that acts as a regulator of
oxygen (O2) homeostasis in metazoan species by binding to hypoxia response elements …

Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

Hypoxia-inducible factors (HIFs) activate transcription of target genes by recruiting
coactivators and chromatin-modifying enzymes. Peptidylarginine deiminase 4 (PADI4) …

Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited
therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation …

Hypoxia is the major influence factor in physiological and pathological courses which are
mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions …

Altered epigenetic reprogramming contributes to breast cancer progression and metastasis.
How the epigenetic reader mediates breast cancer progression remains poorly understood …