The endocannabinoid system: a potential target for the treatment of various diseases

H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Modulating the endocannabinoid system in human health and disease–successes and failures

P Pacher, G Kunos - The FEBS journal, 2013 - Wiley Online Library
The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

P Pacher, R Mechoulam - Progress in lipid research, 2011 - Elsevier
The mammalian body has a highly developed immune system which guards against
continuous invading protein attacks and aims at preventing, attenuating or repairing the …

The role of the endocannabinoid system in the brain–gut axis

KA Sharkey, JW Wiley - Gastroenterology, 2016 - Elsevier
The actions of cannabis are mediated by receptors that are part of an endogenous
cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring …

Cannabinoids and the gut: new developments and emerging concepts

AA Izzo, KA Sharkey - Pharmacology & therapeutics, 2010 - Elsevier
Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …

Targeting cannabinoid signaling in the immune system:“High”-ly exciting questions, possibilities, and challenges

A Oláh, Z Szekanecz, T Bíró - Frontiers in Immunology, 2017 - frontiersin.org
It is well known that certain active ingredients of the plants of Cannabis genus, ie, the
“phytocannabinoids”[pCBs; eg,(−)-trans-Δ9-tetrahydrocannabinol (THC),(−)-cannabidiol …

Complementary and alternative medicines used by patients with inflammatory bowel diseases

AS Cheifetz, R Gianotti, R Luber, PR Gibson - Gastroenterology, 2017 - Elsevier
Patients and physicians often have many questions regarding the role of complementary
and alternative medicines (CAMs), or nonallopathic therapies, for inflammatory bowel …

Cannabinoids and autoimmune diseases: A systematic review

V Katchan, P David, Y Shoenfeld - Autoimmunity reviews, 2016 - Elsevier
Cannabinoids have shown to have a variety effects on body systems. Through CB1 and CB2
receptors, amongst other, they exert an effect by modulating neurotransmitter and cytokine …

A randomized, double-blind, placebo-controlled, parallel-group, pilot study of cannabidiol-rich botanical extract in the symptomatic treatment of ulcerative colitis

PM Irving, T Iqbal, C Nwokolo… - Inflammatory bowel …, 2018 - academic.oup.com
Background Cannabidiol (CBD) exhibits anti-inflammatory properties that could improve
disease activity in inflammatory bowel disease. This proof-of-concept study assessed …

Endocannabinoid system as a promising therapeutic target in inflammatory bowel disease–a systematic review

S Hryhorowicz, M Kaczmarek-Ryś, A Zielińska… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is a general term used to describe a group of chronic
inflammatory conditions of the gastrointestinal tract of unknown etiology, including two …