Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML)
have revealed a striking heterogeneity with regard to the presence of acquired gene …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation
(TET) 2 gene have been described in various human myeloid malignancies. We report that …

The impact of ten-eleven-translocation 2 (TET2) mutations on response to azacitidine (AZA)
in MDS has not been reported. We sequenced the TET2 gene in 86 MDS and acute myeloid …

Abstract Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation,
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …

DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer,
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …

The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …

The studies concerning clinical implications of TET2 mutation in patients with primary acute
myeloid leukemia (AML) are scarce. We analyzed TET2 mutation in 486 adult patients with …

Purpose To determine the frequency of TET2 mutations, their associations with clinical and
molecular characteristics and outcome, and the associated gene-and microRNA-expression …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults that affects the
myeloid lineage. The recent advances have upgraded our understanding of the cytogenetic …