Anticancer activity of diosgenin and its semi-synthetic derivatives: role in autophagy mediated cell death and induction of apoptosis

N Bhardwaj, N Tripathi, B Goel… - Mini Reviews in …, 2021 - ingentaconnect.com
During cancer progression, the unrestricted proliferation of cells is supported by the
impaired cell death response provoked by certain oncogenes. Both autophagy and …

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion

F Kopp, CF Stratton, LB Akella, DS Tan - Nature chemical biology, 2012 - nature.com
Macrocycles are key structural elements in numerous bioactive small molecules and are
attractive targets in the diversity-oriented synthesis of natural product–based libraries …

Steroids: partial synthesis in medicinal chemistry

JR Hanson - Natural Product Reports, 2007 - pubs.rsc.org
Covering: January–December 2006 This article reviews the progress in the chemistry of the
steroids which was published between January and December 2006. The reactions and …

Diosgenin-based thio (seleno) ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile

LL Romero-Hernandez, P Merino-Montiel… - European Journal of …, 2015 - Elsevier
The stereoselective preparation of diosgenin-derived thio (seleno) ureas and glycomimetics
bearing a 1, 2, 3-triazolyl tether on C-3 has been accomplished. The key steps in the …

Synthesis of 26-hydroxy-22-oxocholestanic frameworks from diosgenin and hecogenin and their in vitro antiproliferative and apoptotic activity on human cervical …

MA Fernández-Herrera, H López-Muñoz… - Bioorganic & Medicinal …, 2010 - Elsevier
Certain steroidal compounds have demonstrated an antiproliferative effect against several
tumor cell lines; however, their complete role on cancer cells is not currently established …

Synthesis of the steroidal glycoside (25R)-3β, 16β-diacetoxy-12, 22-dioxo-5α-cholestan-26-yl β-D-glucopyranoside and its anti-cancer properties on cervicouterine …

MA Fernández-Herrera, S Mohan… - European journal of …, 2010 - Elsevier
The synthesis of the new glycoside (25R)-3β, 16β-diacetoxy-12, 22-dioxo-5α-cholestan-26-
yl β-d-glucopyranoside starting from hecogenin is described. This compound showed anti …

[PDF][PDF] Cytotoxicity of Secondary Metabolites from Dracaena viridiflora Engl & Krause and their Semisynthetic Analogues.

RB Teponno, JP Dzoyem, RN Nono, U Kauhl… - Records of Natural …, 2017 - acgpubs.org
The MeOH extract of Dracaena viridiflora was found to display significant cytotoxicity against
some cancer cell lines. Systematic phytochemical investigation of this extract led to the …

Diosgenone synthesis, anti-malarial activity and QSAR of analogues of this natural product

A Pabón, G Escobar, E Vargas, V Cruz, R Notario… - Molecules, 2013 - mdpi.com
Solanum nudum Dunal steroids have been reported as being antimalarial compounds;
however, their concentration in plants is low, meaning that the species could be threatened …

Synthesis and biological evaluation of the glycoside (25R)-3β, 16β-diacetoxy-22-oxocholest-5-en-26-yl β-d-glucopyranoside: a selective anticancer agent in …

MA Fernández-Herrera, H López-Muñoz… - European journal of …, 2011 - Elsevier
The synthesis and biological evaluation of the new cholestane glycoside (25R)-3β, 16β-
diacetoxy-22-oxocholest-5-en-26-yl β-d-glucopyranoside starting from diosgenin is …

Ulososides and Urabosides — Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox

J Colorado, D Muñoz, D Marquez, ME Marquez… - Molecules, 2013 - mdpi.com
Three new triterpene glycosides, named ulososide F (1), urabosides A (2) and B (3),
together with the previously reported ulososide A (4), were isolated from the Caribbean …