Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor
activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin …

The primary cilium has recently stepped into the spotlight, as a flood of data show that this
organelle has crucial roles in vertebrate development and human genetic diseases. Cilia …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during
embryonic development and adult tissue homeostasis. Here we review the current …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate
various cellular processes; however, their role in liver fibrosis is unclear. Here we investigate …