On the 400th anniversary of Harvey's Lumleian lectures, this review focuses on
“hemodynamic” forces associated with the movement of blood through arteries in humans …

Background Vascular dysfunction is a precursor to the atherosclerotic cascade, significantly
increasing susceptibility to cardiovascular events such as myocardial infarction or stroke …

The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

Regular exercise has multi-system anti-aging effects. Here we summarize how exercise
impacts the major hallmarks of aging. We propose that, besides searching for novel …

Background Regular exercise is associated with enhanced nitric oxide (NO) bioavailability.
Flow-mediated dilation (FMD) is used widely to assess endothelial function (EF) and NO …

Vascular endothelial function is essential for maintenance of health of the vessel wall and for
vasomotor control in both conduit and resistance vessels. These functions are due to the …

In humans, exercise training and moderate to high levels of physical activity are protective
against cardiovascular disease. In fact they are∼ 40% more protective than predicted based …

Epidemiological studies suggest that physically active individuals have a 30–50% lower risk
of developing type 2 diabetes than do sedentary persons and that physical activity confers a …

Endothelium is essential for maintenance of health of the vessel wall and for the local
regulation of vascular tone and structure and haemostasis. Regular physical exercise, which …

In the past two decades, normal endothelial function has been identified as integral to
vascular health. The endothelium produces numerous vasodilator and vasoconstrictor …