The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents
GM Kowalski, CR Bruce - American Journal of Physiology …, 2014 - journals.physiology.org
The incidence of insulin resistance and type 2 diabetes (T2D) is increasing at alarming
rates. In the quest to understand the underlying causes of and to identify novel therapeutic …
rates. In the quest to understand the underlying causes of and to identify novel therapeutic …
Androgen receptor in human endothelial cells
V Torres-Estay, DV Carreno… - Journal of …, 2015 - joe.bioscientifica.com
The heart is an insulin-dependent and energy-consuming organ in which insulin and
nutritional signaling integrates to the regulation of cardiac metabolism, growth and survival …
nutritional signaling integrates to the regulation of cardiac metabolism, growth and survival …
[HTML][HTML] Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry
Z Li, M Peng, P Chen, C Liu, A Hu, Y Zhang, J Peng… - Cell Metabolism, 2022 - cell.com
Summary Coronavirus disease 2019 (COVID-19) represents a systemic disease that may
cause severe metabolic complications in multiple tissues including liver, kidney, and …
cause severe metabolic complications in multiple tissues including liver, kidney, and …
AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate …
SL Pinkosky, S Filippov, RAK Srivastava… - Journal of lipid …, 2013 - ASBMB
ETC-1002 (8-hydroxy-2, 2, 14, 14-tetramethylpentadecanedioic acid) is a novel
investigational drug being developed for the treatment of dyslipidemia and other cardio …
investigational drug being developed for the treatment of dyslipidemia and other cardio …
Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption
X Li, J Yang, X Zhou, C Dai, M Kong, L Xie, C Liu… - Nature …, 2024 - nature.com
The low-carbohydrate ketogenic diet (KD) has long been practiced for weight loss, but the
underlying mechanisms remain elusive. Gut microbiota and metabolites have been …
underlying mechanisms remain elusive. Gut microbiota and metabolites have been …
N-acyl taurines and acylcarnitines cause an imbalance in insulin synthesis and secretion provoking β cell dysfunction in type 2 diabetes
M Aichler, D Borgmann, J Krumsiek, A Buck… - Cell metabolism, 2017 - cell.com
The processes contributing to β cell dysfunction in type 2 diabetes (T2D) are uncertain,
largely because it is difficult to access β cells in their intact immediate environment. We …
largely because it is difficult to access β cells in their intact immediate environment. We …
Repurposing drugs to target the diabetes epidemic
Despite major investment by pharmaceutical companies in conventional drug discovery
pipelines, development of new drugs has failed to keep up with the increasing incidence of …
pipelines, development of new drugs has failed to keep up with the increasing incidence of …
Carbonic anhydrase 1-mediated calcification is associated with atherosclerosis, and methazolamide alleviates its pathogenesis
L Yuan, M Wang, T Liu, Y Lei, Q Miao, Q Li… - Frontiers in …, 2019 - frontiersin.org
Vascular calcification is an important pathogenic process in atherosclerosis (AS); however,
its immediate cause is unknown. Our previous study demonstrated that carbonic anhydrase …
its immediate cause is unknown. Our previous study demonstrated that carbonic anhydrase …
Safety of carbonic anhydrase inhibitors
ER Swenson - Expert opinion on drug safety, 2014 - Taylor & Francis
Introduction: Carbonic anhydrase (CA) inhibitors have an impressive safety record despite
the multiple functions that CA isozymes serve because they are not fully inhibited with most …
the multiple functions that CA isozymes serve because they are not fully inhibited with most …
Methazolamide attenuates the development of diabetic cardiomyopathy by promoting β-catenin degradation in type 1 diabetic mice
X Chen, Y Li, X Yuan, W Yuan, C Li, Y Zeng, Y Lian… - Diabetes, 2022 - Am Diabetes Assoc
Methazolamide (MTZ), a carbonic anhydrase inhibitor, has been shown to inhibit
cardiomyocyte hypertrophy and exert a hypoglycemic effect in patients with type 2 diabetes …
cardiomyocyte hypertrophy and exert a hypoglycemic effect in patients with type 2 diabetes …