Oncolytic adenoviruses for the treatment of human cancer: focus on translational and clinical data

S Pesonen, L Kangasniemi… - Molecular …, 2011 - ACS Publications
Although results of cancer treatment have improved steadily, metastatic solid tumors can be
cured only rarely and therefore new modalities are needed. Tumors often become apoptosis …

Virotherapy: From single agents to combinatorial treatments

AM Malfitano, S Di Somma, CA Iannuzzi… - Biochemical …, 2020 - Elsevier
Virotherpay is emerging as a promising strategy against cancer, and three oncolytic viruses
(OVs) have gained approval in different countries for the treatment of several cancer types …

Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4

JD Dias, O Hemminki, I Diaconu, M Hirvinen, A Bonetti… - Gene therapy, 2012 - nature.com
Promising clinical results have been achieved with monoclonal antibodies (mAbs) such as
ipilimumab and tremelimumab that block cytotoxic T lymphocyte-associated antigen-4 …

CD44 interacts with EGFR and promotes head and neck squamous cell carcinoma initiation and progression

A Perez, DM Neskey, J Wen, L Pereira, EP Reategui… - Oral oncology, 2013 - Elsevier
OBJECTIVES: CD44 is a promising target for therapy in head and neck squamous cell
carcinoma (HNSCC) and has two defined roles in tumorigenesis: it is a cancer stem cell …

[HTML][HTML] Antitumor activity of photo-stimulated zinc oxide nanoparticles combined with paclitaxel or cisplatin in HNSCC cell lines

S Hackenberg, A Scherzed, W Harnisch… - … of Photochemistry and …, 2012 - Elsevier
Zinc oxide nanoparticles (ZnO-NPs) exhibit photocatalytic properties and are used in
sunscreen cosmetics and for the degradation of environmental pollutants. Furthermore, ZnO …

Zinc oxide nanoparticles induce photocatalytic cell death in human head and neck squamous cell carcinoma cell lines in vitro

S Hackenberg, A Scherzed… - International …, 2010 - spandidos-publications.com
The aim of this study was to determine the photocatalytic effects of zinc oxide (ZnO) NPs in
combination with UVA-1 in human head and neck squamous cell carcinoma (HNSCC) cell …

Use and Safety of Intratumoral Application of European Mistletoe (Viscum album L) Preparations in Oncology

ML Steele, J Axtner, A Happe, M Kröz… - Integrative Cancer …, 2015 - journals.sagepub.com
Background. Intratumoral (IT) injection of European mistletoe (Viscum album L) preparations
might induce local tumor response through combined cytotoxic and immunomodulatory …

Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of …

CM Chang, PY Chang, MG Tu, CC Lu… - Oncology …, 2012 - spandidos-publications.com
Human head and neck squamous cell carcinoma (HNSCC) is a major cause of cancer-
related death during the last decade due to its related metastasis and poor treatment …

Evaluation of human mesenchymal stromal cells as carriers for the delivery of oncolytic HAdV-5 to head and neck squamous cell carcinomas

R Nilson, L Krutzke, F Wienen, M Rojewski, PH Zeplin… - Viruses, 2023 - mdpi.com
Human multipotent mesenchymal stromal cells (hMSCs) are of significant therapeutic
interest due to their ability to deliver oncolytic adenoviruses to tumors. This approach is also …

Enhanced oncolysis mediated by Coxsackievirus A21 in combination with doxorubicin hydrochloride

KA Skelding, RD Barry, DR Shafren - Investigational new drugs, 2012 - Springer
Virotherapy is an emerging strategy for the treatment of cancer that utilizes both replication-
competent and genetically modified viruses to selectively kill tumor cells. We have …