Background Osteocytes, composing over 90% of bone cells, are well known for their
mechanosensing abilities. Aged osteocytes with impaired morphology and function are less …

Bone is a mechanosensitive tissue for which mechanical stimuli are crucial in maintaining its
structure and function. Bone cells react to their biomechanical environment by activating …

Fracture-related infection (FRI) is a devastating complication in orthopedic surgery. A recent
study showed that FRI causes more severe infection and further delays healing in …

Magnesium metal and its alloys are being developed as effective orthopedic implants;
however, the mechanisms underlying the actions of magnesium on bones remain unclear …

Background Cell culture studies demonstrate the importance of β3 integrin in osteocyte
mechanotransduction. However, the in vivo roles of osteocyte β3 integrin in the regulation of …

Abstract Fibroblast growth factor 23 (FGF23) has been casually linked to numerous
hypophosphatemic bone diseases, however connection with bone loss or fragility fractures …

Recent years have witnessed an evolution of imaging technologies towards sophisticated
approaches for visualising cells within their natural environment (s) and for investigating …

The purpose of this study was to investigate the effect of load-induced local mechanical
strain on bone cell activity of peri-implant bone in mice. Titanium implants were placed in the …

The prevalence of osteoporotic fracture is high due to global aging problem. Delayed and
impaired healing in osteoporotic fractures increase the socioeconomic burden significantly …

Abstract Purpose of Review The purpose of this review is to summarize the clinical and
basic science methods used to assess fracture healing and propose a framework to improve …