The immunological and metabolic landscape in primary and metastatic liver cancer

X Li, P Ramadori, D Pfister, M Seehawer… - Nature Reviews …, 2021 - nature.com
The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

Notch signaling in vascular endothelial cells, angiogenesis, and tumor progression: an update and prospective

A Akil, AK Gutiérrez-García, R Guenter… - Frontiers in cell and …, 2021 - frontiersin.org
The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Metastasis organotropism: redefining the congenial soil

Y Gao, I Bado, H Wang, W Zhang, JM Rosen… - Developmental cell, 2019 - cell.com
Metastasis is the most devastating stage of cancer progression and causes the majority of
cancer-related deaths. Clinical observations suggest that most cancers metastasize to …

Precision medicine for human cancers with Notch signaling dysregulation

M Katoh, M Katoh - International journal of molecular …, 2020 - spandidos-publications.com
Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …

[HTML][HTML] Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling

M Winkler, T Staniczek, SW Kürschner, CD Schmid… - Journal of …, 2021 - Elsevier
Background & Aims Angiocrine signaling by liver sinusoidal endothelial cells (LSECs)
regulates hepatic functions such as growth, metabolic maturation, and regeneration …

The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver

AL Wilkinson, M Qurashi, S Shetty - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

M Singhal, N Gengenbacher, AA Abdul Pari… - Science translational …, 2021 - science.org
Metastasis is the primary cause of cancer-related mortality. Tumor cell interactions with cells
of the vessel wall are decisive and potentially rate-limiting for metastasis. The molecular …

Angiodiversity and organotypic functions of sinusoidal endothelial cells

PS Koch, KH Lee, S Goerdt, HG Augustin - Angiogenesis, 2021 - Springer
Abstract 'Angiodiversity'refers to the structural and functional heterogeneity of endothelial
cells (EC) along the segments of the vascular tree and especially within the microvascular …

[HTML][HTML] The role of liver sinusoidal endothelial cells in cancer liver metastasis

M Yang, C Zhang - American Journal of Cancer Research, 2021 - ncbi.nlm.nih.gov
Liver sinusoidal endothelial cells (LSECs) are the gatekeeper cells in the liver, contributing
critical roles in liver physiological and pathological changes. Factors such as dietary …

Liver immune microenvironment and metastasis from colorectal cancer-pathogenesis and therapeutic perspectives

X Zeng, SE Ward, J Zhou, ASL Cheng - Cancers, 2021 - mdpi.com
Simple Summary Liver metastasis remains the major contributor in colorectal cancer-related
death. It has become clear that the unique immune features of liver microenvironment take …