The immunological and metabolic landscape in primary and metastatic liver cancer
X Li, P Ramadori, D Pfister, M Seehawer… - Nature Reviews …, 2021 - nature.com
The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …
Notch signaling in vascular endothelial cells, angiogenesis, and tumor progression: an update and prospective
A Akil, AK Gutiérrez-García, R Guenter… - Frontiers in cell and …, 2021 - frontiersin.org
The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …
processes including cell fate determination of vascular endothelial cells and the regulation …
Metastasis organotropism: redefining the congenial soil
Metastasis is the most devastating stage of cancer progression and causes the majority of
cancer-related deaths. Clinical observations suggest that most cancers metastasize to …
cancer-related deaths. Clinical observations suggest that most cancers metastasize to …
Precision medicine for human cancers with Notch signaling dysregulation
M Katoh, M Katoh - International journal of molecular …, 2020 - spandidos-publications.com
Abstract NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …
transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL) 1, DLL3, DLL4 …
[HTML][HTML] Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling
M Winkler, T Staniczek, SW Kürschner, CD Schmid… - Journal of …, 2021 - Elsevier
Background & Aims Angiocrine signaling by liver sinusoidal endothelial cells (LSECs)
regulates hepatic functions such as growth, metabolic maturation, and regeneration …
regulates hepatic functions such as growth, metabolic maturation, and regeneration …
The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver
AL Wilkinson, M Qurashi, S Shetty - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …
Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis
M Singhal, N Gengenbacher, AA Abdul Pari… - Science translational …, 2021 - science.org
Metastasis is the primary cause of cancer-related mortality. Tumor cell interactions with cells
of the vessel wall are decisive and potentially rate-limiting for metastasis. The molecular …
of the vessel wall are decisive and potentially rate-limiting for metastasis. The molecular …
Angiodiversity and organotypic functions of sinusoidal endothelial cells
PS Koch, KH Lee, S Goerdt, HG Augustin - Angiogenesis, 2021 - Springer
Abstract 'Angiodiversity'refers to the structural and functional heterogeneity of endothelial
cells (EC) along the segments of the vascular tree and especially within the microvascular …
cells (EC) along the segments of the vascular tree and especially within the microvascular …
[HTML][HTML] The role of liver sinusoidal endothelial cells in cancer liver metastasis
Liver sinusoidal endothelial cells (LSECs) are the gatekeeper cells in the liver, contributing
critical roles in liver physiological and pathological changes. Factors such as dietary …
critical roles in liver physiological and pathological changes. Factors such as dietary …
Liver immune microenvironment and metastasis from colorectal cancer-pathogenesis and therapeutic perspectives
Simple Summary Liver metastasis remains the major contributor in colorectal cancer-related
death. It has become clear that the unique immune features of liver microenvironment take …
death. It has become clear that the unique immune features of liver microenvironment take …