The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Metabolites once considered solely in catabolism or anabolism turn out to have key
regulatory functions. Among these, the citric acid cycle intermediate succinate stands out …

Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …

Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However,
excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species …

The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O2,
glucose, and other nutrients diffuse out of the choroid and then filter through a monolayer of …

Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …

Mitochondrial complex I is central to the pathological reactive oxygen species (ROS)
production that underlies cardiac ischemia–reperfusion (IR) injury. ND6-P25L mice are …

Background: Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor
malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for …

Succinate is a circulating metabolite, and the relationship between abnormal changes in the
physiological concentration of succinate and inflammatory diseases caused by the …

There has been an explosion of interest in the signaling capacity of energy metabolites. A
prime example is the Krebs cycle substrate succinate, an archetypal respiratory substrate …