The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Abstract Purpose of Review Mechanisms facilitating progression of hypertension via cross
stimulation of the renin-angiotensin system (RAS) and inflammation have been proposed …

There is growing interest in the pharmaceutical and medical applications of 20-
hydroxyecdysone (20E), a polyhydroxylated steroid which naturally occurs in low but very …

Skeletal muscle injuries occur frequently in daily life and exercise. Understanding the
mechanisms of regeneration is critical for accelerating the repair and regeneration of …

Skeletal muscle is a tissue that shows the most plasticity in the body; it can change in
response to physiological and pathological stimuli. Among the diseases that affect skeletal …

The regulation of stem cells that maintain and regenerate postnatal tissues depends on
extrinsic signals originating from their microenvironment, commonly referred to as the stem …

Background Impaired muscle regeneration and increased muscle fibrosis are observed in
aged muscle accompanied by progressive loss of muscle mass (sarcopenia). However, the …

Background Fluorescent-activated cell sorting (FACS) has enabled the direct isolation of
highly enriched skeletal muscle stem cell, or satellite cell, populations from postnatal tissue …

Sarcopenia and cachexia are muscle wasting syndromes associated with aging and with
many chronic diseases, such as congestive heart failure (CHF), diabetes, cancer, chronic …

Clinicians and scientists working in the field of regenerative engineering are actively
investigating a wide range of methods to promote musculoskeletal tissue regeneration …