Type 1 diabetes is a chronic, immune-mediated disease characterised by the destruction of
insulin-producing cells. Standardised registry data show that type 1 diabetes incidence has …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

We analyzed the effects of a single 14-day course of teplizumab treatment on metabolic
function and immune cells among participants in a previously reported randomized …

Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …

Aims/hypothesis It is unclear whether type 1 diabetes is a single disease or if endotypes
exist. Our aim was to use a unique collection of pancreas samples recovered soon after …

Abstract Type 1 diabetes (T1D)—an autoimmune disease that destroys the pancreatic islets,
resulting in insulin deficiency—often begins early in life when islet autoantibody appearance …

Viruses are implicated in autoimmune destruction of pancreatic islet β cells, which results in
insulin deficiency and type 1 diabetes (T1D),,–. Certain enteroviruses can infect β cells in …

Despite major advances over the past decade, prevention and treatment of type 1 diabetes
mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual …

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …

Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …