Mediterranean spotted fever (MSF) is an emerging tick-borne rickettsiosis of the spotted
fever group (SFG), endemic in the Mediterranean basin. By virtue of technological …

Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …

Detection of the presence of infection and its etiology must be accurate and timely to
facilitate appropriate antimicrobial use. Diagnostic strategies that rely solely on pathogen …

While most bacterial species taken up by macrophages are degraded through processing of
the bacteria-containing vacuole through the endosomal-lysosomal degradation pathway …

Rickettsia amblyommatis belongs to the spotted fever group of Rickettsia and infects
Amblyomma americanum (Lone Star ticks) for transmission to offspring and mammals …

Through long-term interactions with their hosts, bacterial pathogens have evolved unique
arsenals of effector proteins that interact with specific host targets and reprogram the host …

Orientia tsutsugamushi is an obligately intracellular bacterium and the etiological agent of
scrub typhus. The lung is a major target organ of infection, displaying type 1-skewed …

Rickett s ial agents are a diverse group of alpha-proteobacteria within the order
Rickettsiales, which possesses two families with human pathogens, Rickettsiaceae and …

Intracellular pathogens alter their host cells' mechanics to promote dissemination through
tissues. Conversely, host cells may respond to the presence of pathogens by altering their …

Rickettsia are significant sources of tick-borne diseases in humans worldwide. In North
America, two species in the spotted fever group of Rickettsia have been conclusively …