Experimental models of epilepsy are useful to identify potential mechanisms of epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …
Temporal lobe epilepsy is a common, chronic neurological disorder characterized by recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that …
V Iori, AM Iyer, T Ravizza, L Beltrame, L Paracchini… - Neurobiology of …, 2017 - Elsevier
We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL- 1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability …
A Jimenez-Pacheco, M Diaz-Hernandez… - Journal of …, 2016 - Soc Neuroscience
Neuroinflammation is thought to contribute to the pathogenesis and maintenance of temporal lobe epilepsy, but the underlying cell and molecular mechanisms are not fully …
G Liu, B Gu, XP He, RB Joshi, HD Wackerle… - Neuron, 2013 - cell.com
Temporal lobe epilepsy is the most common and often devastating form of human epilepsy. The molecular mechanism underlying the development of temporal lobe epilepsy remains …
TW Lin, SC Harward, YZ Huang, JO McNamara - Neuropharmacology, 2020 - Elsevier
Traumatic brain injury (TBI) and status epilepticus (SE) have both been linked to development of human epilepsy. Although distinct etiologies, current research has …
J Hau, SJ Schapiro, GL Van Hoosier Jr - 2004 - taylorfrancis.com
Building upon the success of the Handbook of Laboratory Animal Science and completing Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …
A Jimenez‐Pacheco, G Mesuret, A Sanz‐Rodriguez… - …, 2013 - Wiley Online Library
Purpose ATP is an essential transmitter/cotransmitter in neuron function and pathophysiology and has recently emerged as a potential contributor to prolonged seizures …
F Frigerio, G Pasqualini, I Craparotta, S Marchini… - Brain, 2018 - academic.oup.com
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying mechanisms of the disease (epileptogenesis). There are no treatments for preventing …