The kainic acid model of temporal lobe epilepsy

M Lévesque, M Avoli - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
The kainic acid model of temporal lobe epilepsy has greatly contributed to the
understanding of the molecular, cellular and pharmacological mechanisms underlying …

The kainic acid models of temporal lobe epilepsy

E Rusina, C Bernard, A Williamson - Eneuro, 2021 - eneuro.org
Experimental models of epilepsy are useful to identify potential mechanisms of
epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) …

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

EM Jimenez-Mateos, T Engel, P Merino-Serrais… - Nature medicine, 2012 - nature.com
Temporal lobe epilepsy is a common, chronic neurological disorder characterized by
recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that …

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

V Iori, AM Iyer, T Ravizza, L Beltrame, L Paracchini… - Neurobiology of …, 2017 - Elsevier
We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-
1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability …

Transient P2X7 receptor antagonism produces lasting reductions in spontaneous seizures and gliosis in experimental temporal lobe epilepsy

A Jimenez-Pacheco, M Diaz-Hernandez… - Journal of …, 2016 - Soc Neuroscience
Neuroinflammation is thought to contribute to the pathogenesis and maintenance of
temporal lobe epilepsy, but the underlying cell and molecular mechanisms are not fully …

Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy

G Liu, B Gu, XP He, RB Joshi, HD Wackerle… - Neuron, 2013 - cell.com
Temporal lobe epilepsy is the most common and often devastating form of human epilepsy.
The molecular mechanism underlying the development of temporal lobe epilepsy remains …

Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy

TW Lin, SC Harward, YZ Huang, JO McNamara - Neuropharmacology, 2020 - Elsevier
Traumatic brain injury (TBI) and status epilepticus (SE) have both been linked to
development of human epilepsy. Although distinct etiologies, current research has …

[图书][B] Handbook of laboratory animal science: Animal Models, Volume III

J Hau, SJ Schapiro, GL Van Hoosier Jr - 2004 - taylorfrancis.com
Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

Increased neocortical expression of the P 2X7 receptor after status epilepticus and anticonvulsant effect of P 2X7 receptor antagonist A‐438079

A Jimenez‐Pacheco, G Mesuret, A Sanz‐Rodriguez… - …, 2013 - Wiley Online Library
Purpose ATP is an essential transmitter/cotransmitter in neuron function and
pathophysiology and has recently emerged as a potential contributor to prolonged seizures …

n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis

F Frigerio, G Pasqualini, I Craparotta, S Marchini… - Brain, 2018 - academic.oup.com
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying
mechanisms of the disease (epileptogenesis). There are no treatments for preventing …