Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

Environmental metabolomics: a critical review and future perspectives

JG Bundy, MP Davey, MR Viant - Metabolomics, 2009 - Springer
Environmental metabolomics is the application of metabolomics to characterise the
interactions of organisms with their environment. This approach has many advantages for …

Environmental metabolomics: an emerging approach to study organism responses to environmental stressors

BP Lankadurai, EG Nagato… - Environmental …, 2013 - cdnsciencepub.com
Metabolomics is the analysis of endogenous and exogenous low molecular mass
metabolites within a cell, tissue, or biofluid of an organism in response to an external …

NMR spectroscopy in environmental research: From molecular interactions to global processes

AJ Simpson, DJ McNally, MJ Simpson - Progress in Nuclear Magnetic …, 2011 - Elsevier
Our environment is essential for not only the quality, but also the persistence of life on Earth.
Three of the most pressing environmental issues facing modern society are climate change …

Ecological metabolomics: overview of current developments and future challenges

J Sardans, J Penuelas, A Rivas-Ubach - Chemoecology, 2011 - Springer
Ecometabolomics, which aims to analyze the metabolome, the total number of metabolites
and its shifts in response to environmental changes, is gaining importance in ecological …

Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures

DJ Spurgeon, OAH Jones, JLCM Dorne… - Science of the total …, 2010 - Elsevier
Environmental mixtures of chemicals constitute a prevalent issue in ecotoxicology and the
development of new methods to reduce the uncertainties associated with their ecological …

NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology

M Coen, E Holmes, JC Lindon… - Chemical research in …, 2008 - ACS Publications
We have reviewed the main contributions to the development of NMR-based metabonomic
and metabolic profiling approaches for toxicological assessment, biomarker discovery, and …

Ecotoxicogenomic approaches for understanding molecular mechanisms of environmental chemical toxicity using aquatic invertebrate, Daphnia model organism

HJ Kim, P Koedrith, YR Seo - International Journal of Molecular Sciences, 2015 - mdpi.com
Due to the rapid advent in genomics technologies and attention to ecological risk
assessment, the term “ecotoxicogenomics” has recently emerged to describe integration of …

Recent developments in environmental metabolomics

MR Viant - Molecular Biosystems, 2008 - pubs.rsc.org
Metabolomics is increasingly being used to characterise the interactions of organisms with
their natural environment. This article describes the latest developments in this vibrant field …

'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus

JG Bundy, JK Sidhu, F Rana, DJ Spurgeon… - BMC biology, 2008 - Springer
Background New methods are needed for research into non-model organisms, to monitor
the effects of toxic disruption at both the molecular and functional organism level. We …