Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds
endogenous antioxidant capacity. In this paper, we review the specific role of several …

Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Type 2 diabetes is a chronic metabolic disease that affects mitochondrial function. In this
context, the rescue mechanisms of mitochondrial health, such as mitophagy and …

Mitochondria are an essential component of multicellular life–from primitive organisms, to
highly complex entities like mammals. The importance of mitochondria is underlined by their …

Significance: Diabetic cardiomyopathy (DCM) is a frequent complication occurring even in
well-controlled asymptomatic diabetic patients, and it may advance to heart failure (HF) …

Mitochondrial medicine is increasingly discussed as a promising therapeutic approach,
given that mitochondrial defects are thought to contribute to many prevalent diseases and …

Diabetes is a global epidemic and a leading cause of death with more than 422 million
patients worldwide out of whom around 392 million alone suffer from type 2 diabetes (T2D) …

Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …

Patients with preexisting cardiovascular disease or those at high risk for developing the
condition are often offered exercise as a form of therapy. Patients with cancer who are at an …