Methods of generating submicrometer phase-shift perfluorocarbon droplets for applications in medical ultrasonography

PS Sheeran, N Matsuura, MA Borden… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Continued advances in the field of ultrasound and ultrasound contrast agents have created
new approaches to imaging and medical intervention. Phase-shift perfluorocarbon droplets …

On the thermodynamics and kinetics of superheated fluorocarbon phase-change agents

PA Mountford, MA Borden - Advances in colloid and interface science, 2016 - Elsevier
Superheated nanodrops are a new class of submicron-diameter liquid emulsion particles
comprising perfluoropropane (C 3 F 8), perfluorobutane (C 4 F 10) and perfluoropentane (C …

Transcutaneous imaging of rabbit kidney using 3-D acoustic wave sparsely activated localization microscopy with a row-column-addressed array

Q Tan, K Riemer, J Hansen-Shearer… - IEEE Transactions …, 2024 - ieeexplore.ieee.org
Objective: Super-resolution ultrasound (SRUS) imaging through localizing and tracking
microbubbles, also known as ultrasound localization microscopy (ULM), can produce sub …

From micro-to nano-multifunctional theranostic platform: effective ultrasound imaging is not just a matter of scale

S Zullino, M Argenziano, I Stura, C Guiot… - Molecular …, 2018 - journals.sagepub.com
Ultrasound Contrast Agents (UCAs) consisting of gas-filled-coated Microbubbles (MBs) with
diameters between 1 and 10 µm have been used for a number of decades in diagnostic …

More than bubbles: creating phase-shift droplets from commercially available ultrasound contrast agents

PS Sheeran, K Yoo, R Williams, M Yin, FS Foster… - Ultrasound in medicine …, 2017 - Elsevier
Phase-shift perfluorocarbon droplets have been investigated for over 20 years as pre-
clinical ultrasound contrast agents with distinctive advantages in imaging and therapy. A …

Fast and selective super-resolution ultrasound in vivo with acoustically activated nanodroplets

K Riemer, M Toulemonde, J Yan… - … on Medical Imaging, 2022 - ieeexplore.ieee.org
Perfusion by the microcirculation is key to the development, maintenance and pathology of
tissue. Its measurement with high spatiotemporal resolution is consequently valuable but …

Acoustic nanodrops for biomedical applications

MA Borden, G Shakya, A Upadhyay… - Current opinion in colloid & …, 2020 - Elsevier
Acoustic nanodrops are designed to vaporize into ultrasound-responsive microbubbles,
which present certain challenges nonexistent for conventional nanoemulsions. The …

Control of acoustic cavitation for efficient sonoporation with phase-shift nanoemulsions

MT Burgess, TM Porter - Ultrasound in medicine & biology, 2019 - Elsevier
Acoustic cavitation can be used to temporarily disrupt cell membranes for intracellular
delivery of large biomolecules. Termed sonoporation, the ability of this technique for efficient …

Sequential payload release from acoustically-responsive scaffolds using focused ultrasound

A Moncion, M Lin, OD Kripfgans, RT Franceschi… - Ultrasound in medicine …, 2018 - Elsevier
Regenerative processes, such as angiogenesis and osteogenesis, often require multiple
growth factors with distinct spatiotemporal patterns and expression sequences. Within tissue …

Investigating the accumulation of submicron phase-change droplets in tumors

BL Helfield, K Yoo, J Liu, R Williams… - Ultrasound in Medicine …, 2020 - Elsevier
Submicron phase-change droplets are an emerging class of ultrasound contrast agent.
Compared with microbubbles, their relatively small size and increased stability offer the …