Present-day treatments for people that are insulin dependent require multiple insulin
injections, sometimes with an insulin pump, coupled with regular blood glucose monitoring …

Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young
patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes …

We report the 1-year results from one patient as the preliminary analysis of a first-in-human
phase I clinical trial (ChiCTR2300072200) assessing the feasibility of autologous …

Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The
cellular and molecular defects that cause the disease remain unknown. Pluripotent cells …

The generation of insulin-producing β-cells from human pluripotent stem cells is dependent
on efficient endoderm induction and appropriate patterning and specification of this germ …

Human induced pluripotent stem (iPS) cells are similar to embryonic stem (ES) cells, and
can proliferate intensively and differentiate into a variety of cell types. However, the hepatic …

Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type,
and one widely recognized goal is to make pancreatic β cells. To this end, comparisons …

Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are
considered attractive sources of pancreatic β cells and islet organoids. Recently, several …

Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin,
there has been an increasing interest in the study of undifferentiated progenitors that have …

The state of a cell is defined by the genes it transcribes and the epigenetic landscape that
regulates their expression. Pluripotent cells have markedly different epigenetic signatures …