Despite much recent progress, prostate cancer continues to represent a major cause of
cancer-related mortality and morbidity in men. Since early studies on the role of the …

Despite major improvement in treatment of early stage localised prostate cancer, the
distinction between indolent tumors and those that will become aggressive, as well as the …

BACKGROUND The role of Wnt/β‐Catenin signaling in embryogenesis and carcinogenesis
has been extensively studied in organs such as colon, lung and pancreas, but little is known …

The human prostate is a gland of the male reproductive tract, which together with the
seminal vesicles, is responsible for most seminal fluid production. It is a common site of …

Androgens initiate a complex network of signals within the UGS that trigger prostate lineage
commitment and bud formation. Given its contributions to organogenesis in other systems …

We have shown previously that during branching morphogenesis of the mouse prostate
gland, Bone morphogenetic protein 7 functions to restrict Notch1-positive progenitor cells to …

The prostate is a branched ductal‐acinar gland that is part of the male reproductive tract.
Prostate development depends upon the integration of steroid hormone signals, paracrine …

Serum response factor (SRF) is a ubiquitously expressed transcription factor that binds a 10-
bp element known as the CArG box, located in the proximal regulatory region of hundreds of …

ABSTRACT Introduction Prostate cancer (PCa) is a complex, heterogenous and multifocal
disease, which is debilitating for patients and often fatal–due to bone metastasis and …

Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during
development and carcinogenesis. Nkx3. 1-mediated Cre expression is a useful strategy to …