Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective

TM Kylkilahti, E Berends, M Ramos… - Journal of Cerebral …, 2021 - journals.sagepub.com
Age-related neurodegenerative diseases are a growing burden to society, and many are
sporadic, meaning that the environment, diet and lifestyle play significant roles …

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

MS Albayram, G Smith, F Tufan, IS Tuna… - Nature …, 2022 - nature.com
Meningeal lymphatic vessels have been described in animal studies, but limited comparable
data is available in human studies. Here we show dural lymphatic structures along the dural …

Conserved meningeal lymphatic drainage circuits in mice and humans

L Jacob, J de Brito Neto, S Lenck, C Corcy… - Journal of Experimental …, 2022 - rupress.org
Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of
the dura mater, where they ensure waste product elimination and immune surveillance of …

Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood

MJP van Osch, A Wåhlin, P Scheyhing… - NMR in …, 2024 - Wiley Online Library
Over the last decade, it has become evident that cerebrospinal fluid (CSF) plays a pivotal
role in brain solute clearance through perivascular pathways and interactions between the …

Prospective T1 mapping to assess gadolinium retention in brain after intrathecal gadobutrol

G Ringstad, LM Valnes, SAS Vatnehol, AH Pripp… - Neuroradiology, 2023 - Springer
Purpose A possible pathway behind gadolinium retention in brain is leakage of contrast
agents from blood to cerebrospinal fluid and entry into brain along perivascular (glymphatic) …

Intrathecal contrast-enhanced magnetic resonance imaging of cerebrospinal fluid dynamics and glymphatic enhancement in idiopathic normal pressure …

PK Eide, A Lashkarivand, ÅA Hagen-Kersten… - Frontiers in …, 2022 - frontiersin.org
Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease,
characterized by cerebrospinal fluid (CSF) flow disturbance. Today, the only available …

Prospective safety study of intrathecal gadobutrol in different doses

A Sperre, I Karsrud, AHS Rodum… - American Journal …, 2023 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: In our clinical practice, we increasingly use intrathecal
contrast-enhanced glymphatic MR imaging to assess CSF disturbances. However, because …

Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols

M Halvorsen, CS Edeklev, J Fraser-Green, G Løvland… - Neuroradiology, 2021 - Springer
Purpose Magnetic resonance imaging (MRI) contrast agents have been used off-label for
diagnosis of cerebrospinal fluid (CSF) leaks and lately also for assessment of the glymphatic …

Concurrent measurement of perfusion parameters related to small blood vessels and cerebrospinal fluid circulation in the human brain using dynamic dual‐spin‐echo …

D Cao, Y Sun, Y Li, P Su, JJ Pillai, Y Qiao… - NMR in …, 2023 - Wiley Online Library
Accumulating evidence from recent studies has indicated the importance of studying the
interaction between the microvascular and lymphatic systems in the brain. To date, most …

Characterizing cerebrospinal fluid mobility using heavily T2-weighted 3D fast spin echo (FSE) imaging with improved multi-directional diffusion-sensitized driven …

L Ran, Y He, J Zhu, F Long, Y Dong… - Journal of Cerebral …, 2024 - journals.sagepub.com
Cerebrospinal fluid (CSF) flow patterns and their relationship with arterial pulsation can
depict the function of glymphatic system (GS). We propose an improved multi-directional …