Recent developments in chemical reactivity of N, N-dimethylenamino ketones as synthons for various heterocycles

HM Gaber, MC Bagley, ZA Muhammad, SM Gomha - RSC advances, 2017 - pubs.rsc.org
The current review presents recent progress in the utility of N, N-dimethyl enaminones as
building blocks for a diverse range of acyclic, carbocyclic, five-and six-membered …

Molecular docking simulation and anticancer assessment on human breast carcinoma cell line using novel bis (1, 4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile) and …

SK Salama, MF Mohamed, AF Darweesh… - Bioorganic …, 2017 - Elsevier
An efficient route for the synthesis of novel bis (1, 4-dihydropyrano [2, 3-c] pyrazole-5-
carbonitrile) derivatives is reported. The synthetic pathway involves one pot, synthesis of bis …

Organocatalysis in Synthesis: L-Proline as an Enantioselective Catalyst in the Synthesis of Pyrans and Thiopyrans

NMH Elnagdi, NS Al-Hokbany - molecules, 2012 - mdpi.com
The multicomponent reaction (MCR) of aromatic aldehydes 1 and malononitrile (2) with
active methylenes 5a–h in the presence of l-proline produced pyrans and thiopyrans 6a–h …

Synthesis, characterization, DNA photocleavage, in silico and in vitro DNA/BSA binding properties of novel hexahydroquinolines

MA Ragheb, RS Omar, MH Soliman… - Journal of Molecular …, 2022 - Elsevier
A simple, and efficient procedure has been developed for the synthesis of novel 2-(4-
(hexahydroquinolin-4-yl) phenoxy)-N-arylacetamides and thieno [3′, 2′: 5, 6] pyrimido [1 …

Isoxazolyl-Derived 1,4-Dihydroazolo[5,1-c][1,2,4]Triazines: Synthesis and Photochemical Properties

EV Sadchikova, NE Safronov, NA Beliaev… - Molecules, 2023 - mdpi.com
New fluorescent dyes containing an assembled 1, 4-dihydroazolo [5, 1-c][1, 2, 4] triazine
(DAT) core and an isoxazole ring were synthesized through a reaction between …

Synthesis, cytotoxicity and molecular docking simulation of novel bis-1, 4-dihydropyridines linked to aliphatic or arene core via amide or ester-amide linkages

AM Abdella, AM Abdelmoniem… - Mini Reviews in …, 2020 - ingentaconnect.com
Objective: Novel bis (1, 4-dihydropyridine-3, 5-dicarbonitrile) derivatives linked to aliphatic
or aromatic cores via amide or ester-amide linkages were prepared and their structures …

Benzimidazoazapurines: design, synthesis, and photophysical study

VV Fedotov, EN Ulomsky, NP Belskaya… - The Journal of …, 2021 - ACS Publications
A highly efficient approach to a new class of polycyclic 8-azapurines, benzo [4, 5] imidazo [1,
2-a][1, 2, 3] triazolo [4, 5-e] pyrimidines (BITPs), with good photophysical characteristics is …

[PDF][PDF] Enamines as precursors to polyfunctional heteroaromatic compounds; a decade of development

SM Riyadh, IA Abdelhamid, HM Al-Matar… - …, 2008 - triggered.edina.clockss.org
Recent synthesis and utilization of enamines as precursors for heterocyclic and carbocyclic
compounds are reviewed. Two general synthetic routes for preparation of enamines based …

DBU-Catalyzed, facile and efficient method for synthesis of spirocyclic 2-oxindole derivatives with incorporated 6-amino-4H-pyridazines and fused derivatives via [3+ 3 …

IA Abdelhamid, MH Mohamed, AM Abdelmoniem… - Tetrahedron, 2009 - Elsevier
3-Cyanomethylidene oxindole derivatives were prepared in excellent yields utilizing DBU-
promoted Knoevenagel condensation of isatin derivatives with active methylene reagents …

Enaminone incorporating a dibromobenzofuran moiety: versatile precursor for novel azines and azolotriazines

SMH Sanad, AEM Mekky - Journal of Heterocyclic Chemistry, 2018 - Wiley Online Library
2‐Acetyl‐5, 7‐dibromobenzo [b] furan (1) reacted with dimethylformamide‐dimethylacetal to
give the corresponding (E)‐enaminone 3 which coupled with aromatic diazonium chloride to …