Uterine fibroids: hiding in plain sight

EA Stewart, RA Nowak - Physiology, 2022 - journals.physiology.org
Uterine fibroids (leiomyomas) are present in> 75% of women and can cause serious
morbidity. They are by far the leading cause of hysterectomy. Fibroids are a complex mixture …

Association between obesity and the risk of uterine fibroids: a systematic review and meta-analysis

H Qin, Z Lin, E Vásquez, X Luan, F Guo… - J Epidemiol Community …, 2021 - jech.bmj.com
Background Uterine fibroids (UFs) are the most common form of sex steroid hormone-
dependent benign tumours that grow in the walls of the uterus. Several observational …

Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types

K Buyukcelebi, AJ Duval, F Abdula, H Elkafas… - Nature …, 2024 - nature.com
Uterine fibroids (UF), that can disrupt normal uterine function and cause significant physical
and psychological health problems, are observed in nearly 70% of women of reproductive …

Update on the role and regulatory mechanism of extracellular matrix in the pathogenesis of uterine fibroids

Q Yang, A Al-Hendy - International Journal of Molecular Sciences, 2023 - mdpi.com
Uterine fibroids (UFs), also known as leiomyomas, are benign tumors of the myometrium
affecting over 70% of women worldwide, particularly women of color. Although benign, UFs …

Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids

MS Islam, M Parish, JT Brennan, BL Winer… - Scientific reports, 2023 - nature.com
Fibrosis is characterized by excessive accumulation of extracellular matrix, which is a key
feature of uterine fibroids. Our prior research supports the tenet that inhibition of fibrotic …

Activin and inhibin signaling: from regulation of physiology to involvement in the pathology of the female reproductive system

EA Adu-Gyamfi, FT Djankpa, W Nelson, A Czika… - Cytokine, 2020 - Elsevier
Activins and inhibins–comprising activin A, B, AB, C and E, and inhibin A and B isoforms–
belong to the transforming growth factor beta (TGFβ) superfamily. They regulate several …

[HTML][HTML] Mechanical stiffness augments ligand-dependent progesterone receptor B activation via MEK 1/2 and Rho/ROCK–dependent signaling pathways in uterine …

CNC Mitchell, MS Islam, S Afrin, J Brennan, KJ Psoter… - Fertility and sterility, 2021 - Elsevier
Objective To test whether mechanical substrate stiffness would influence progesterone
receptor B (PRB) signaling in fibroid cells. Uterine fibroids feature an excessive extracellular …

Curcumol, a major terpenoid from Curcumae Rhizoma, attenuates human uterine leiomyoma cell development via the p38MAPK/NF-κB pathway

YH Yu, HJ Zhang, F Yang, L Xu, H Liu - Journal of Ethnopharmacology, 2023 - Elsevier
Abstract Ethnopharmacological relevance Uterine fibroids (UFs) are the most common
benign tumors in women of reproductive age. Curcumae Rhizoma, the main essential oil …

Activin a secreted from peripheral nerve fibroblasts promotes proliferation and migration of Schwann cells

Y Li, Z Cheng, F Yu, Q Zhang, S Yu, F Ding… - Frontiers in Molecular …, 2022 - frontiersin.org
The peripheral nervous system has remarkable regenerative capabilities. Schwann cells
and fibroblasts are known to play crucial roles in these processes. In this study, we …

Pathogenic role of the sphingosine 1-phosphate (S1P) pathway in common gynecologic disorders (GDs): A possible novel therapeutic target

A Di Paolo, A Vignini, S Alia, V Membrino… - International Journal of …, 2022 - mdpi.com
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid, noteworthy for its involvement
both in the modulation of various biological processes and in the development of many …