Eosinophilia is a common finding in drug hypersensitivity reactions (DHR). Its cause is
unclear, as neither antigen/allergen‐driven inflammation nor clonal expansion is involved …

Withanolides represent an important category of natural products with a steroidal lactone
core. Many of them contain an α, β-unsaturated carbonyl moiety with a high reactivity toward …

Mice with a loss-of-function mutation in the LAT adaptor (LatY136F) develop an autoimmune
and type 2 inflammatory disorder called defective LAT signalosome pathology (DLSP). We …

Introduction ZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates
a TCR signaling cascade upon antigen stimulation. Mutations in the ZAP70 gene cause a …

Mutations affecting T-cell receptor (TCR) signaling typically cause combined
immunodeficiency (CID) due to varying degrees of disturbed T-cell homeostasis and …

Inflammation is a major mechanism of photoreceptor cell death in the retina during macular
degeneration leading to the blindness. In this study, we investigated the role of the kinase …

Heart failure (HF) is a terminal condition of multiple cardiovascular disorders. Cancer is a
deadly disease worldwide. The relationship between HF and cancer remains poorly …

The catfish industry is the largest sector of US aquaculture production. Given its role in food
production, the catfish immune response to industry-relevant pathogens has been …

Gibel carp (Carassius auratus gibelio) is an important economically farmed fish in China.
Chilodonella hexasticha parasitizes on the gills and fins of host fish, causing disruption to …

Background The morphological attributes could serve as pivotal indicators precipitating
early recurrence and dismal overall survival in hepatocellular carcinoma (HCC), and …