Serotonin is an important brain neurotransmitter that is relevant to depression, migraine, and
other neuropsychiatric illnesses. It has been estimated that about 95% of serotonin is found …

Background The nonselective 5‐HT 4 receptor agonists, cisapride and tegaserod have been
associated with cardiovascular adverse events (AEs). Aim To perform a systematic review of …

Neurohumoral substances and their receptors play a major part in the complex regulation of
gastrointestinal motility and have therefore been the predominant targets for drug …

Hydroxytryptamine4 (5‐HT4) receptors are an interesting target for the management of
patients in need of gastrointestinal (GI) promotility treatment. They have proven therapeutic …

Abstract Serotonin (5-hydroxytryptamine or 5-HT) plays a critical physiological role in the
regulation of gastrointestinal (GI) function. 5-HT dysfunction may also be involved in the …

Prucalopride is a novel enterokinetic compound and is the first representative of the
benzofuran class. We set out to establish its pharmacological profile in various receptor …

Gastrointestinal motility disorders represent a diagnostic and therapeutic challenge.
Disorders of gastrointestinal motility may result in accelerated transit, delayed transit …

Recent research has provided new information about drugs that could be used to treat
functional motility disorders. Promotility drugs accelerate gastric emptying or colonic transit …

Background Gastrointestinal sensorimotor dysfunction underlies a wide range of
esophageal, gastric, and intestinal motility and functional disorders that collectively …

Chronic constipation (CC) is a highly prevalent and often under-appreciated gastrointestinal
disorder associated with significant impairment in quality of life. Symptoms of constipation …