Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Mechanotransduction is a fundamental ability that allows living organisms to receive and
respond to physical signals from both the external and internal environments. The …

Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

The evolutionarily conserved Piezo channel family, including Piezo1 and Piezo2 in
mammals, serves as versatile mechanotransducers in various cell types and consequently …

The extravasation of leukocytes is a critical step during inflammation that requires the
localized opening of the endothelial barrier. This process is initiated by the close interaction …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1
channel as a mediator of mechanically activated calcium ion entry and the PECAM1 cell …

The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors,
yet the link between it and the ubiquitously expressed mechanosensitive ion channel …

Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian
cells. The distribution of Piezo1 within a cell is essential for various biological processes …

Epithelial and endothelial cells experience numerous mechanical cues throughout their
lifetimes. Cells resist these forces by fortifying their cytoskeletal networks and adhesions …