Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …
immune responses. They also provide a frontline of host defense in the central nervous …
[HTML][HTML] TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease
Y Li, H Xu, H Wang, K Yang, J Luan, S Wang - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease, resulting in the
loss of cognitive ability and memory. However, there is no specific treatment to …
loss of cognitive ability and memory. However, there is no specific treatment to …
Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice
Alzheimer's disease, the most common age-related neurodegenerative disease, is
characterized by tau aggregation and associated with disrupted circadian rhythms and …
characterized by tau aggregation and associated with disrupted circadian rhythms and …
[HTML][HTML] Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of
Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully …
Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully …
Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development
Triggering receptor expressed on myeloid cells 2 (Trem2) is a myeloid cell-specific gene
expressed in brain microglia, with variants that are associated with neurodegenerative …
expressed in brain microglia, with variants that are associated with neurodegenerative …
Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation
Microglia are important players in surveillance and repair of the brain. Implanting an
electrode into the cortex activates microglia, produces an inflammatory cascade, triggers the …
electrode into the cortex activates microglia, produces an inflammatory cascade, triggers the …
Soluble TREM2 concentrations in the cerebrospinal fluid correlate with the severity of neurofibrillary degeneration, cognitive impairment, and inflammasome activation …
E Španić Popovački, M Babić Leko… - Neurology …, 2023 - mdpi.com
Background: Individuals with specific TREM2 gene variants that encode for a Triggering
Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer's disease …
Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer's disease …
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine
The importance of neuroinflammation in neurodegenerative diseases is becoming
increasingly evident, and, in parallel, human induced pluripotent stem cell (hiPSC) models …
increasingly evident, and, in parallel, human induced pluripotent stem cell (hiPSC) models …
Amelioration of signaling deficits underlying metabolic shortfall in TREM2R47H human iPSC‐derived microglia
F Vasilopoulou, TM Piers, J Wei, J Hardy… - The FEBS …, 2024 - Wiley Online Library
The microglial triggering receptor expressed on myeloid cells 2 (TREM2) is required for
diverse microglia responses in neurodegeneration, including immunometabolic plasticity …
diverse microglia responses in neurodegeneration, including immunometabolic plasticity …
TREM2 and microglia exosomes: a potential highway for pathological tau
N Jain, JD Ulrich - Molecular neurodegeneration, 2022 - Springer
Tau pathology appears to spread along neuronal networks via the template misfolding of tau
by pathological tau conformations. The mechanisms underlying neuron-to-neuron …
by pathological tau conformations. The mechanisms underlying neuron-to-neuron …