Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

Neurobiology of rodent self-grooming and its value for translational neuroscience

AV Kalueff, AM Stewart, C Song, KC Berridge… - Nature Reviews …, 2016 - nature.com
Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing
pattern and is one of the most frequently performed behavioural activities in rodents. In this …

[HTML][HTML] mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

M Pagani, N Barsotti, A Bertero, S Trakoshis… - Nature …, 2021 - nature.com
Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …

[HTML][HTML] Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment

MJ Millan, K Fone, T Steckler, WP Horan - European …, 2014 - Elsevier
Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

J Ellegood, E Anagnostou, BA Babineau… - Molecular …, 2015 - nature.com
Autism is a heritable disorder, with over 250 associated genes identified to date, yet no
single gene accounts for> 1–2% of cases. The clinical presentation, behavioural symptoms …

Large-scale functional connectivity networks in the rodent brain

A Gozzi, AJ Schwarz - Neuroimage, 2016 - Elsevier
Abstract Resting-state functional Magnetic Resonance Imaging (rsfMRI) of the human brain
has revealed multiple large-scale neural networks within a hierarchical and complex …

[HTML][HTML] Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes

V Zerbi, M Pagani, M Markicevic, M Matteoli… - Molecular …, 2021 - nature.com
Abstract Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly
heterogeneous abnormalities in functional brain connectivity. However, the origin and …

[HTML][HTML] The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to …

P Sen, E Sherwin, K Sandhu, TFS Bastiaanssen… - Brain, behavior, and …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by deficits
in social behaviour, increased repetitive behaviour, anxiety and gastrointestinal symptoms …

Imaging sex/gender and autism in the brain: etiological implications

MC Lai, JP Lerch, DL Floris… - Journal of …, 2017 - Wiley Online Library
The male preponderance in autism prevalence has brought together the disparate topics of
sex/gender and autism research. Two directions of neuroimaging studies on the …

The BTBR mouse model of idiopathic autism–current view on mechanisms

KZ Meyza, DC Blanchard - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
Autism spectrum disorder (ASD) is the most commonly diagnosed neurodevelopmental
disorder, with current estimates of more than 1% of affected children across nations. The …