Type 2 diabetes mellitus (T2DM) causes peripheral vascular disease because of which
several blood-borne factors, including vital nutrients fail to reach the affected tissue. Tissue …

An extreme chronic wound tissue microenvironment causes epigenetic gene silencing. An
unbiased whole-genome methylome was studied in the wound-edge tissue of patients with …

Wound healing is a well-organized dynamic process involving coordinated consecutive
phases: homeostasis, inflammation, proliferation and resolution. Fibroblasts play major roles …

Tissue nanotransfection (TNT), a cutting-edge technique of in vivo gene therapy, has gained
substantial attention in various applications ranging from in vivo tissue reprogramming in …

Extracellular vesicles (EVs) are nanovesicles released by all eukaryotic cells. This work
reports the first nanoscale fluorescent visualization of tumor-originating vesicles bearing an …

Critical limb ischemia (CLI) is caused by severe arterial blockage with reduction of blood
flow. The aim of this study was to determine whether therapeutic angiogenesis using cellular …

The α-tocotrienol (TCT) form of natural vitamin E is more potent than the better known α-
tocopherol against stroke. Angiographic studies of canine stroke have revealed beneficial …

Macrophages assume diverse phenotypes and functions in response to cues from the
microenvironment. Earlier we reported an anti-inflammatory effect of Collagenase Santyl® …

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetic
Foot Consortium (DFC) was established in September 2018 by the NIDDK to build an …

Human death marks the end of organismal life under conditions such that the components of
the human body continue to be alive. Such postmortem cellular survival depends on the …