Simple Summary A large number of studies report that medicinal herbs and many food
ingredients protect against the development of liver disease because they possess …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Liver fibrosis has evolved in the past 20 years from a pure laboratory discipline to an area of
great bedside relevance to practicing hepatologists. This evolution reflects growing awarenessnotonlyofthemolecularunderpinn …

Encapsulation of injury with fibrosis is a highly evolved response of adult tissues. In liver, the
components of the process have been greatly clarified, leading to a coherent view of how …

Liver fibrosis can be considered as a dynamic and highly integrated cellular response to
chronic liver injury [1]. Whatever the etiology, the evolution of chronic liver disease (CLD) is …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue
environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have …

Introduction 3. Paracrine soluble factors regulating hepatic stellate cell activation 3.1.
Transforming growth factor-beta 3.2. Tumor necrosis factor-alpha 3.3. Endothelins 3.4 …

Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …

The present study investigated the preventive effect of eugenol, a naturally occurring food
flavouring agent on thioacetamide (TA)-induced hepatic injury in rats. Adult male Wistar rats …