Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Rationale: Mutations in the transcription factor TBX20 (T-box 20) are associated with
congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development …

CDKN1B haploinsufficiency promotes the development of several human cancers. The gene
encodes p27Kip1, a protein playing pivotal roles in the control of growth, differentiation …

Cdc6 is the AAA+ ATPase that assembles prereplicative complexes on replication origins in
eukaryotic chromosomes. Recently, the same Cdc6 protein was found to exert two more …

Abstract Cell Division Cycle 6 (Cdc6) is a component of pre-replicative complex (preRC)
forming on DNA replication origins in eukaryotes. Recessive mutations in ORC1, ORC4 …

PIN1 is a peptidyl-prolyl isomerase that catalyzes the cis/trans isomerization of peptide
bonds between proline and phosphorylated serine/threonine residues. By changing the …

Cdc6 is the bifunctional AAA+ ATPase that assembles prereplicative complexes on origins
of replication and activates p21 CIP1-or p27 KIP1-bound Cdk2. During the G 1-S transition …

The centrosome serves as a major microtubule-organizing center (MTOC). The Cdc6 protein
is a component of the pre-replicative complex and a licensing factor for the initiation of …

p27Kip1 is a critical modulator of cell proliferation by controlling assembly, localization and
activity of cyclin-dependent kinase (CDK). p27Kip1 also plays important roles in malignant …

The human papillomavirus (HPV) plays a central role in cervical carcinogenesis and its
oncogene E7 is essential in this process. We showed here that E7 abrogated the G1 cell …