Artificial intelligence for multimodal data integration in oncology

J Lipkova, RJ Chen, B Chen, MY Lu, M Barbieri… - Cancer cell, 2022 - cell.com
In oncology, the patient state is characterized by a whole spectrum of modalities, ranging
from radiology, histology, and genomics to electronic health records. Current artificial …

Artificial intelligence in histopathology: enhancing cancer research and clinical oncology

A Shmatko, N Ghaffari Laleh, M Gerstung, JN Kather - Nature cancer, 2022 - nature.com
Artificial intelligence (AI) methods have multiplied our capabilities to extract quantitative
information from digital histopathology images. AI is expected to reduce workload for human …

Harnessing multimodal data integration to advance precision oncology

KM Boehm, P Khosravi, R Vanguri, J Gao… - Nature Reviews …, 2022 - nature.com
Advances in quantitative biomarker development have accelerated new forms of data-driven
insights for patients with cancer. However, most approaches are limited to a single mode of …

The impact of site-specific digital histology signatures on deep learning model accuracy and bias

FM Howard, J Dolezal, S Kochanny, J Schulte… - Nature …, 2021 - nature.com
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …

Swarm learning for decentralized artificial intelligence in cancer histopathology

OL Saldanha, P Quirke, NP West, JA James… - Nature medicine, 2022 - nature.com
Artificial intelligence (AI) can predict the presence of molecular alterations directly from
routine histopathology slides. However, training robust AI systems requires large datasets …

Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology

NG Laleh, HS Muti, CML Loeffler, A Echle… - Medical image …, 2022 - Elsevier
Artificial intelligence (AI) can extract visual information from histopathological slides and
yield biological insight and clinical biomarkers. Whole slide images are cut into thousands of …

Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study

SJ Wagner, D Reisenbüchler, NP West, JM Niehues… - Cancer Cell, 2023 - cell.com
Deep learning (DL) can accelerate the prediction of prognostic biomarkers from routine
pathology slides in colorectal cancer (CRC). However, current approaches rely on …

Deep learning model for the prediction of microsatellite instability in colorectal cancer: a diagnostic study

R Yamashita, J Long, T Longacre, L Peng… - The Lancet …, 2021 - thelancet.com
Background Detecting microsatellite instability (MSI) in colorectal cancer is crucial for clinical
decision making, as it identifies patients with differential treatment response and prognosis …

Deficient mismatch repair/microsatellite unstable colorectal cancer: Diagnosis, prognosis and treatment

J Taieb, M Svrcek, R Cohen, D Basile… - European Journal of …, 2022 - Elsevier
Microsatellite unstable (MSI) colorectal cancers (CRCs) are due to DNA mismatch repair
(MMR) deficiency and occurs in15% of non-metastatic diseases and 5% in the metastatic …

[HTML][HTML] Artificial intelligence in liver diseases: Improving diagnostics, prognostics and response prediction

D Nam, J Chapiro, V Paradis, TP Seraphin, JN Kather - Jhep Reports, 2022 - Elsevier
Clinical routine in hepatology involves the diagnosis and treatment of a wide spectrum of
metabolic, infectious, autoimmune and neoplastic diseases. Clinicians integrate qualitative …