Obligate protozoan parasites of the kinetoplastids and apicomplexa infect human cells to
complete their life cycles. Some of the members of these groups of parasites develop in at …

Malaria is still one of the major killer parasitic diseases in tropical settings, posing a public
health threat. The development of antimalarial drug resistance is reversing the gains made …

Research on Plasmodium parasites has driven breakthroughs in reducing malaria morbidity
and mortality. Experimental analysis of in vivo/ex vivo versus in vitro samples serve unique …

Protozoan parasites cause diverse diseases with large global impacts. Research on the
pathogenesis and biology of these organisms is limited by economic and experimental …

African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T.
brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat …

Objectives Efficacy is determined not only by size, but also by shape, of drug exposure. Here
the critical importance of the temporal pattern of drug concentrations (pharmacokinetic …

Trypanosoma brucei subspecies cause African sleeping sickness in humans, an infection
that is commonly fatal if not treated, and available therapies are limited. Previous studies …

Antibacterial drugs are an important component of malaria therapy. We studied the
interactions of clindamycin, tetracycline, chloramphenicol, and ciprofloxacin against …

The ansamycin antibiotic geldanamycin is biosynthesized by Streptomyces hygroscopicus
through a PKS type I. The macrolactamization in the biosynthesis is catalyzed by the amide …

African Trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T.
brucei) and is spread by the tsetse fly in sub-Saharan Africa. The disease is fatal if left …