Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

Electroneutral cation-Cl− cotransporters compose a family of solute carriers in which cation
(Na+ or K+) movement through the plasma membrane is always accompanied by Cl− in a 1 …

The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric
oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which …

Asymmetric (NG, NG)-dimethylarginine (ADMA) inhibits nitric oxide (NO) synthases (NOS).
ADMA is a risk factor for endothelial dysfunction, cardiovascular mortality, and progression …

Significance: Renal oxidative stress can be a cause, a consequence, or more often a
potentiating factor for hypertension. Increased reactive oxygen species (ROS) in the kidney …

Hypertension is among the most prevalent and catastrophic chronic diseases worldwide.
While the efficacy of renin angiotensin system (RAS) blockade in lowering blood pressure …

The kidney plays an essential role in blood pressure regulation by controlling short-term and
long-term NaCl and water balance. The thick ascending limb of the loop of Henle (TAL) …

Nitric oxide (NO) plays an important role in various physiological processes in the kidney. In
vivo experiments first suggested that the natriuretic and diuretic effects caused by NO may …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

The balance between vasoconstrictor/sodium-retaining and vasodilator/natriuretic systems
is essential for maintaining body fluid and electrolyte homeostasis. Natriuretic peptides, such …