Interaction of cells with the extracellular matrix is fundamental to a wide variety of biological
processes, such as cell proliferation, cell migration, embryogenesis, and organization of …

Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol
biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro …

Proximity-dependent biotin labeling (BioID) may identify new targets for cancers driven by
difficult-to-drug oncogenes such as Ras. Therefore, BioID was used with wild-type (WT) and …

Abstract The HRAS, NRAS, and KRAS genes are collectively mutated in a fifth of all human
cancers. These mutations render RAS GTP-bound and active, constitutively binding effector …

Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute one of the
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …

Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute a family of
sterol and phosphoinositide binding proteins conserved in eukaryotes. The mechanisms of …

Talin is a 270‐kDa protein that activates integrins and couples them to cytoskeletal actin.
Talin contains an N‐terminal FERM domain comprised of F1, F2 and F3 domains, but it is …

In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or
HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS …

The results from the randomized phase II BELOB trial provided evidence for a potential
benefit of bevacizumab (beva), a humanized monoclonal antibody against circulating VEGF …

Rap proteins are Ras-like small GTP-binding proteins that amongst others are involved in
the control of cell–cell and cell–matrix adhesion. Several Rap guanine nucleotide exchange …