Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART
is not curative owing to the persistence of replication-competent, latent proviruses in long …

The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1)
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …

Current shock-and-kill strategies for the eradication of the HIV-1 reservoir have resulted in
blips of viremia but not in a decrease in the size of the latent reservoir in patients on …

COVID-19 vaccines have been instrumental tools in reducing the impact of SARS-CoV-2
infections around the world by preventing 80% to 90% of hospitalizations and deaths from …

HIV-1 infection is incurable due to the persistence of the virus in a latent reservoir of resting
memory CD4+ T cells.“Shock-and-kill” approaches that seek to induce HIV-1 gene …

Diterpenes are a class of critical taxonomic markers of the Euphorbiaceae family,
representing small compounds (eg, molecules) with a wide range of biological activities and …

The clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9
system has been used to excise the HIV-1 proviral genome from latently infected cells …

Antiretroviral therapy regimens durably suppress HIV replication, but do not cure infection.
This is partially attributable to the persistence of long-lived pools of resting CD4+ T-cells …

Jan Svoboda studied aspects of viral latency, in particular with respect to disease induction
by avian RNA tumor viruses, which were later renamed as part of the extended retrovirus …