Ventriculitis or post-neurosurgical meningitis or healthcare-associated ventriculitis and
meningitis (VM) is a severe infection that complicates central nervous system operations or …

Drain-associated intracerebral infections are life-threatening emergencies. Their treatment is
challenging due to the limited penetration of antibiotics to the site of infection, resulting in …

Background With current treatment options most patients with CNS TB develop severe
disability or die. Drug-resistant tuberculous meningitis is nearly uniformly fatal. Novel …

Background: Tuberculosis meningitis (TBM) is the most lethal form of TB. It is difficult to treat
in part due to poor or uncertain drug penetration into the central nervous system (CNS). To …

Meropenem is a broad spectrum carbapenem used for the treatment of cerebral infections.
There is a need for data describing meropenem pharmacokinetics (PK) in the brain tissue to …

Background For treatment of ventriculitis, vancomycin and meropenem are frequently used
as empiric treatment but cerebrospinal fluid (CSF) penetration is highly variable and may …

Objectives In difficult-to-treat infections such as nosocomial ventriculitis, meropenem
exposure in the infected compartment is often uncertain but crucial for antibacterial effects …

ABSTRACT A population pharmacokinetic model was developed to describe alterations in
ceftaroline brain disposition caused by meningitis in healthy and methicillin-resistant …

Background Linezolid exposure in critically ill patients is associated with high inter-
individual variability, potentially resulting in subtherapeutic antibiotic exposure. Linezolid …

Die zerebrale Mikrodialyse ist ein minimal-invasives Verfahren, um direkt am Patientenbett
Substanzen im Hirnparenchym innerhalb der Blut-Hirn-Schranke zu bestimmen. Hierfür wird …