A structural and functional perspective of alphavirus replication and assembly
Alphaviruses are small, spherical, enveloped, positive-sense ssRNA viruses responsible for
a considerable number of human and animal diseases. Alphavirus members include …
a considerable number of human and animal diseases. Alphavirus members include …
Layered double hydroxide nanoparticles in gene and drug delivery
Layered double hydroxides (LDHs) have been known for many decades as catalyst and
ceramic precursors, traps for anionic pollutants, catalysts and additives for polymers, but …
ceramic precursors, traps for anionic pollutants, catalysts and additives for polymers, but …
An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates
The coronavirus disease 2019 (COVID-19) pandemic, caused by infection with the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is having a deleterious impact on …
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is having a deleterious impact on …
Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation
To monitor changes in α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor
distribution in living neurons, the AMPA receptor subunit GluR1 was tagged with green …
distribution in living neurons, the AMPA receptor subunit GluR1 was tagged with green …
Replicon-helper systems from attenuated venezuelan equine encephalitis virus: Expression of heterologous genesin vitroand immunization against heterologous …
P Pushko, M Parker, GV Ludwig, NL Davis… - Virology, 1997 - Elsevier
A replicon vaccine vector system was developed from an attenuated strain of Venezuelan
equine encephalitis virus (VEE). The replicon RNA consists of thecis-acting 5′ and 3 …
equine encephalitis virus (VEE). The replicon RNA consists of thecis-acting 5′ and 3 …
trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication
BD Lindenbach, CM Rice - Journal of virology, 1997 - Am Soc Microbiol
Mutational analysis of the nonstructural protein 1 (NS1) of yellow fever virus (YF) has
implicated it in viral RNA replication. To further explore this observation, we sought a method …
implicated it in viral RNA replication. To further explore this observation, we sought a method …
Intramuscular delivery of replicon RNA encoding ZIKV-117 human monoclonal antibody protects against Zika virus infection
JH Erasmus, J Archer, J Fuerte-Stone… - … therapy Methods & …, 2020 - cell.com
Monoclonal antibody (mAb) therapeutics are an effective modality for the treatment of
infectious, autoimmune, and cancer-related diseases. However, the discovery, development …
infectious, autoimmune, and cancer-related diseases. However, the discovery, development …
Methods of activating a melanocortin-4 receptor pathway in obese subjects
LM Kaplan, N Stylopoulos, JL Harris - US Patent 8,476,227, 2013 - Google Patents
Methods and therapeutics are provided for treating metabolic disorders by activation of
melanocortin signaling pathways. Generally, the methods and therapeutics can induce …
melanocortin signaling pathways. Generally, the methods and therapeutics can induce …
Coronavirus reverse genetic systems: infectious clones and replicons
F Almazán, I Sola, S Zuñiga, S Marquez-Jurado… - Virus research, 2014 - Elsevier
Coronaviruses (CoVs) infect humans and many animal species, and are associated with
respiratory, enteric, hepatic, and central nervous system diseases. The large size of the CoV …
respiratory, enteric, hepatic, and central nervous system diseases. The large size of the CoV …
Experience strengthening transmission by driving AMPA receptors into synapses
The mechanisms underlying experience-dependent plasticity in the brain may depend on
the AMPA subclass of glutamate receptors (AMPA-Rs). We examined the trafficking of AMPA …
the AMPA subclass of glutamate receptors (AMPA-Rs). We examined the trafficking of AMPA …