Tau and neuroinflammation in Alzheimer's disease: Interplay mechanisms and clinical translation

Y Chen, Y Yu - Journal of neuroinflammation, 2023 - Springer
Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

[HTML][HTML] Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance

E Salta, O Lazarov, CP Fitzsimons, R Tanzi… - Cell Stem Cell, 2023 - cell.com
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

[HTML][HTML] Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

ER Roy, G Chiu, S Li, NE Propson, R Kanchi, B Wang… - Immunity, 2022 - cell.com
The principal signals that drive memory and cognitive impairment in Alzheimer's disease
(AD) remain elusive. Here, we revealed brain-wide cellular reactions to type I interferon (IFN …

Cellular and pathological functions of tau

C Parra Bravo, SA Naguib, L Gan - Nature Reviews Molecular Cell …, 2024 - nature.com
Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia

S Gaikwad, N Puangmalai, A Bittar, M Montalbano… - Cell reports, 2021 - cell.com
Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a
central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia …

The role of gamma oscillations in central nervous system diseases: Mechanism and treatment

A Guan, S Wang, A Huang, C Qiu, Y Li, X Li… - Frontiers in cellular …, 2022 - frontiersin.org
Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural
oscillations, which are rhythmic electric processes of neuron groups in the brain. The …

Apoe4 and Alzheimer's disease pathogenesis—Mitochondrial deregulation and targeted therapeutic strategies

M Pires, AC Rego - International Journal of Molecular Sciences, 2023 - mdpi.com
APOE ε4 allele (ApoE4) is the primary genetic risk factor for sporadic Alzheimer's disease
(AD), expressed in 40–65% of all AD patients. ApoE4 has been associated to many …

Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Decreased frontal gamma activity in Alzheimer disease patients

EP Casula, MC Pellicciari, S Bonnì, I Borghi… - Annals of …, 2022 - Wiley Online Library
Objective In Alzheimer disease (AD) animal models, synaptic dysfunction has recently been
linked to a disorder of high‐frequency neuronal activity. In patients, a clear relation between …

Role of calcium modulation in the pathophysiology and treatment of Alzheimer's disease

D Baracaldo-Santamaría, SS Avendaño-Lopez… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …