The decades‐old cholinergic hypothesis of Alzheimer's disease (AD) led to clinical testing
and FDA approval of acetylcholinesterase inhibitor drugs. Subsequently, the α7 nicotinic …

BACKGROUND One hundred years ago, experiments on beating frog hearts identified
acetylcholine (ACh) as the seminal neurotransmitter. Sixty years later, fractionation of the eel …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of pentameric, ligand-
gated ion channels that are located on the surface of neurons and non-neuronal cells and …

A deficiency of the functional α7 nicotinic acetylcholine receptor (α7nAChR) impairs
neuronal and immune systems. The SARS-CoV-2 spike protein (S12) facilitates virus cell …

Sepsis-associated encephalopathy (SAE), the most popular cause of coma in the intensive
care unit (ICU), is the diffuse cerebral damage caused by the septic challenge. SAE is …

Gamma-aminobutyric acid type A (GABA A) receptors are the primary inhibitory
neurotransmitter-gated ion channels in the mammalian central nervous system …

The process of how multimeric transmembrane proteins fold and assemble in the
endoplasmic reticulum is not well understood. The alpha7 nicotinic receptor (α7 nAChR) is a …

Mitochondrial dysfunction is a well-established pathological event in Parkinson's disease
(PD). Proteins misfolding and its impaired cellular clearance due to altered …

Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion
channels with members identified in most eumetazoan clades. In vertebrates, they are …

Background Human restricted genes contribute to human specific traits in the immune
system. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of the α7 …