The extracellular matrix (ECM) is a significant factor in cancer progression. Collagens, as the
main component of the ECM, are greatly remodeled alongside cancer development. More …

Many different strategies can be found in the literature to model organ physiology, tissue
functionality, and disease in vitro; however, most of these models lack the physiological fluid …

Mesenchymal stem cells have contributed to the continuous progress of tissue engineering
and regenerative medicine. Adipose‐derived stem cells (ADSC) possess many advantages …

In this work, we show how the mechanical properties of the cellular microenvironment
modulate the growth of tumour spheroids. Based on the composition of the extracellular …

Microengineered systems provide an in vitro strategy to explore the variability of individual
patient response to tissue engineering products, since they prefer the use of primary cell …

Cell migration is a fundamental process that is crucial for many biological functions in the
body such as immune responses and tissue regeneration. Dysregulation of this process is …

Anisotropic collagen/apatite microstructure is a prominent determinant of bone tissue
functionalization; in particular, bone matrix modulates its anisotropic microstructure …

The recent development of bone-on-chips (BOCs) holds the main advantage of requiring a
low quantity of cells and material, compared to traditional In Vitro models. By incorporating …

Introduction Solid tumors consist of tumor cells associated with stromal and immune cells,
secreted factors and extracellular matrix (ECM), which together constitute the tumor …

In silico modeling is a powerful strategy to investigate the biological events occurring at
tissue, cellular and subcellular level during bone fracture healing. However, most current …